Delve into the critical strategies for infection control in orthopaedic trauma surgery, emphasizing the prevention of surgical site infections (SSIs) that can affect patient recovery. Learn about the effective use of Systemic Antibiotic Prophylaxis (SAP), the development of predictive nomograms for assessing SSI risk, and the vital role of non-technical skills in enhancing patient safety and reducing healthcare costs. This overview underscores the importance of a multifaceted approach to improving outcomes in orthopaedic care.